Abstract Book - 26th ESPU Congress, Joint Meeting with ICCS + SPU + AAP/SOU + AAPU + SFU

14:50 - 14:53

S17-5

(PP)

ACQUIRED CRYPTORCHIDISM - MORE HARN THAN THOUGHT?

Martin PROMM

, Josef SCHRÖDER

, Annette SCHRÖDER

, Claudia NEISSNER

, Fabian EDER

and Wolfgang H. RÖSCH

1) Klinik St. Hedwig, University Medical Center of Regensburg, Department of Paediatric Urology,, Regensburg,

GERMANY - 2) University Medical Center of Regensburg, Department of Pathology, Regensburg, GERMANY - 3)

University Medical Center of Regensburg, Department of Paediatric Urology, Regensburg, GERMANY - 4) University

Medical Center of Regensburg, Department of Paediatric Urology, Regensburg, GERMANY

PURPOSE

Since the beginning of this century the acquired cryptorchidism (AC) has been recognized as subgroup of undescended

test. There is growing evidence that the compromising effect equals that of congenital UDT. We performed an extensive

histological examination of biopsies taken from AC in a prospective study.

MATERIAL AND METHODS

From 08/2013 to 12/2014, 21 boys (3-13 years) underwent testicular biopsy during orchidopexy for AC. Germ cell index

was determined by electron-microscopy (GC), as well as the ratio of adult dark spermatogonia (Ad-S) and primary

spermatocytes (PS) per tubule (T). We also scanned for ring-like tubules as a marker for malformation.

Immunohistochemical stains (PLAP, OCT 4) as marker for dystrophy were performed.

RESULTS

Nine (43%) boys had a positive family history for UDT, and 21 (57%) had a patent processus vaginalis. The median for

GC/T, Ad-S/T, and PS/T was 0.7, 0.08, and 0, respectively. Boys below the age of 9 (n= 10) had a significantly higher

number of Ad-S/T and a significantly lower number of PS/T than older boys. There were no ring-like tubules and no

atypic cells. PLAP and OCT 4 stains were negative in all specimens.

CONCLUSIONS

Extensive histopathological examination of AC revealed a significant reduction of germ cell count and fertility markers,

compared to normal values, which worsens with age at surgery. A positive family history appears to be more common in

this group, suggesting the necessity for close follow-up and early surgical intervention, in particular in children with

positive family history.