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S14: HYPOSPADIAS 2
Moderators: Marco Castagnetti (Italy), Pippi Salle (Qatar)
ESPU Meeting on Friday 16, October 2015, 10:26 - 11:26
10:26 - 10:29
S14-1
(PP)
★
PROSPECTIVE STUDY OF A COHORT OF HYPOSPADIAS IN PICARDY REGION
(FRANCE): INCIDENCE AND ANALYSIS OF SYSTEMATIC HORMONAL
EXPLORATIONS, RISK FACTORS AND IMPACT ON THE SEVERITY
Elodie HARAUX
1
, Karine BRAUN
2
, Pierre TOURNEUX
2
, Camille DEVAUCHELLE
2
, Philippe Buisson BUISSON
1
, Jannick
RICARD
1
, Mounia HAMZY
1
, Jean-Pierre CANARELLI
1
, Jean-Pierre CANARELLI
1
, Bernard BOUDAILLIEZ
2
, Veronique BACH
3
and Karen CHARDON
3
1) University Hospital, Pediatric surgery, Amiens Cedex 1, FRANCE - 2) University Hospital, Pediatric unit, Amiens Cedex
1, FRANCE - 3) PeRITOX-INERIS UMR-I-01, CURS - University of Picardy, Amiens Cedex 1, FRANCE
PURPOSE
To evaluate incidence and risk factors for hypospadias in a region of France and to specify their impact on severity of the
malformation.
MATERIAL AND METHODS
Between 2011 and 2014, 57 hypospadias (Hypospadias group (HG), 48 distal (DHG), 9 proximal (6 middle, 3 posterior)
(PHG)) and 162 controls (Control group (CG)) were enrolled in the study. We collected prospectively neonatal and
parental data. We proceeded to hormonal evaluation (FSH, LH, Testosterone, 17OHP at day 1; FSH, LH, AMH, T in
minipuberty) in HG only. We studied with univariate and multivariate analysis risk factors for HG vs CG. Analyze of the
severity of the malformation was also made.
RESULTS
An undescended testis was present on 10.5% of HG vs 2.0% in the CG (OR=5.8 [1.4-8.2]). Eleven of the 39
interpretable blood tests were abnormal. Four hCG tests were abnormal with a 46 XY karyotype and a AR (androgen
receptor) mutation. Two were homozygous twins with distal hypospadias.
In univariate analysis, significant factors comparatively to CG were primiparity in the HG, lower birth weight and length,
higher paternal BMI for the HG and DHG, and low birth weight in PHG group respectively. In multivariate analysis, low
birth weight, paternal medical history, family history of hypospadias and living with pets were significantly more
frequent in HG than in CG.
CONCLUSIONS
Incidence of hypospadias is at least 0.4% of male newborns in our region. In our cohort, 4 newborns had AR mutation.
Our results support the hypothesis of a multifactorial pathology with placental insufficiency and genetic and
environmental disruptions.