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10:43 - 10:47
ICCS S4-6
(SO)
COMPLIANCE TO ANTIMUSCARINICS IN CHILDREN WITH OVERACTIVE BLADDER
Stephane BOLDUC
1
, Alexandra FORTIN
2
and Valerie MORIN
2
1) CHU de Québec-Université Laval, Surgery, Quebec, CANADA - 2) CHU de Québec-Université Laval, Pediatrics,
Quebec, CANADA
PURPOSE
Overactive bladder (OAB) is a common disorder characterized by urinary urgency symptoms ± urinary incontinence.
Symptoms are treated with long-term antimuscarinic medication. Persistence and compliance rates in adults are low
but too little data exists for the paediatric population. Non-compliance can lead to unnecessary escalation of therapy.
The objective of this study was to report on the compliance in children treated for OAB with antimuscarinics.
MATERIAL AND METHODS
Patients presenting OAB (0-18 years old) were recruited at their control visit with a pediatric urologist. After obtaining
consent, we contacted their drugstore enquiring about prescription renewals since beginning of treatment. The
medication possession rate (MPR), (No. days dispensed/No. days between two refills) was calculated and grouped by 3-
month periods. A good compliance was established as a MPR ≥80% every 3-month period and compared to the
compliance reported on a questionnaire.
RESULTS
Seventy-one patients were recruited (mean age: 9.7±2.8 years). They have used the antimuscarinic medication for a
mean of 20±17 months (2565 prescription periods). If we group the periods by 3, 6 or 12 months, a MPR ≥80% was
found in 50.7%, 63.4% and 74.6% of patients respectively. No difference in compliance was found between different
antimuscarinic medications. Patients/parents over-estimated their rate of compliance by 5-10% when compared to the
MPR pharmacy reality.
CONCLUSIONS
Medication compliance is also an important problem in the pediatric population suffering from overactive bladder but
seemed significantly better in our cohort. It has to be addressed and considered in the follow-up of pediatric patients.