Abstract Book - 26th ESPU Congress, Joint Meeting with ICCS + SPU + AAP/SOU + AAPU + SFU

S11: ONCOLOGY

Moderators: Michael Ritchey (USA), Marcel Drlik (Czech Republic)

ESPU Meeting on Thursday 15, October 2015, 16:10 - 16:50

16:10 - 16:15

S11-1

(LO)

★

PROGNOSTIC FACTORS IN PATIENTS WITH BLADDER/PROSTATE

RHABDOMYOSARCOMA UNDERGOING RADICAL SURGERY

Lorenzo ANGELINI

, Gianni BISOGNO

, Rita ALAGGIO

, Giovanni SCARZELLO

, Luisa SANTORO

, Angela SCAGNELLATO

Eleonora BASSO

, Paolo D'ANGELO

, Andrea FERRARI

and Marco CASTAGNETTI

1) University Hospital of Padova, Paediatric Urology, Urology Unit, Padua, ITALY - 2) University Hospital of Padova,

Paediatric Heamtology and Oncology, Padua, ITALY - 3) University Hospital of Padova, Pathology Department, Padua,

ITALY - 4) University Hospital of Padova, Radiotherapy Division, Padua, ITALY - 5) University of Torino, Paediatric

Heamtology and Oncology, Tourin, ITALY - 6) "G. Di Cristina" Children's Hospital, Paediatric Heamtology and Oncology,

Palermo, ITALY - 7) Fondazione IRCCS Istituto Nazionale Tumori, Paediatric Heamtology and Oncology, Milan, ITALY - 8)

University Hospital of Padova, Urology Unit, Section for Paediatric Urology, Padova, ITALY

PURPOSE

We evaluated the prognostic factors in children undergoing radical surgery for bladder/prostate rhabdomyosarcoma (BP-

RMS).

MATERIAL AND METHODS

Between 03/1986 and 10/2014, 108 patients aged 0,3 - 261,2 months, with a BP-RMS were enrolled in 3 subsequent

national protocols (RMS 88, RMS 96 and RMS 2005) coordinated by the Italian soft tissue sarcoma committee. We

reviewed the clinical and surgical data of patients undergoing radical bladder-prostate surgery, and evaluated the

relative risk (RR and 95%CI) for failure of 5-year progression-free survival (5-yr PFS) associated with variables at

diagnosis (age, gender, histology, location, maximum tumour size, and stage), preoperative management (treatment

protocol, tumour response after 9 weeks of treatment, administration of preoperative radiotherapy), and characteristics

of the excised specimen (excision margins, histological differentiation, maximum diameter, the final location of the

tumour).

RESULTS

Data were available in 26 of 30 eligible patients. Of the 26 patients, 17 underwent radical cystoprostatectomy, 5 partial

bladder resection, and 4 radical prostatectomy. 9 events were registered during follow-up [9/26 patients died a median

of 1.76 years (range 0,97- 3.7 years) after surgery]. None of preoperative or management variables appeared to

influence 5-yr PFS including preoperative radiotheraphy. Instead, the presence of an undifferentiated tumour (RR: 4.85;

1.7-14.2; p=0.004), a tumour >5 cm (RR: 3.75; 0.95-14.8; p=0.05), and the simultaneous involvement of both

bladder and prostate (RR: 2.75; 1.1-6.7, p=0.02) on the excised specimen appeared to negatively impact 5-yr PFS.

Finally, 5-yr PFS was unrelated to the presence of positive excision margins.

CONCLUSIONS

Current study confirms that tumours characteristics at presentation do not influence long-term outcome. In patients

undergoing radical bladder-prostate surgery, some characteristics of the removed specimen can influence 5-yr PFS, in

particular a tumor exceeding >5cm in diameter and involving both bladder and prostate, and an undifferentiated

histology are all associated with poorer 5-yr PFS.