Abstract Book - 26th ESPU Congress, Joint Meeting with ICCS + SPU + AAP/SOU + AAPU + SFU

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S19: PRENATAL UROLOGY
Moderators: Antoine Herndon (USA), Abraham Cherian (UK)
ESPU Meeting on Friday 16, October 2015, 16:16 - 16:52
16:16 - 16:19
S19-1 (PP)
★ THE URINARY IP-10, MCP-1, NGAL, CYSTATIN-C AND KIM-1 LEVELS IN
PRENATALLY DIAGNOSED UNILATERAL HYDRONEPHROSIS: THE SEARCH FOR AN
IDEAL BIOMARKER
Tayfun OKTAR1, Serkan KARAKUS1, Canan KUCUKGERGIN 2, Ibrahim KALELIOGLU3, Sule SECKIN2, Irfan DONMEZ1, Arda
ATAR1, Haluk ANDER 1 and Orhan ZIYLAN1
1) Istanbul Faculty of Medicine, Istanbul University, Division of Pediatric Urology, Department of Urology, Istanbul,
TURKEY - 2) Istanbul Faculty of Medicine, Istanbul University, Department of Biochemistry, Istanbul, TURKEY - 3)
Istanbul Faculty of Medicine, Istanbul University, Division of Perinatology, Department of Obstetrics And Gynecology,
Istanbul, TURKEY
PURPOSE
To investigate the urinary IP-10, MCP-1, NGAL, cystatin-C and KIM-1 levels in the management of the children with
prenatally diagnosed unilateral hydronephrosis.
MATERIAL AND METHODS
A total of 27 children with antenatally diagnosed hydronephrosis were enrolled into the study. The controls consisted of
9 healthy children (6 boys, 3 girls; mean age: 41.77±5.30 mos). Of the 27 children, 13 (9 boys, 4 girls; the mean age:
48.46±21.11 mos) underwent pyeloplasty on follow-up and constituted the study group and the remaining 14 (13 boys,
1 girl; mean age: 36.57±14.02 mos) were followed up after being diagnosed as having non-obstructive dilation (NOD).
The urinary IP-10, MCP-1, NGAL, cystatin-C and KIM-1 levels were measured in the study (preoperative and
postoperative), NOD and control groups.
RESULTS
The preoperative concentrations of urinary IP-10, MCP-1, NGAL and KIM-1 were significantly higher in the pyeloplasty
group compared with the controls (p=0.024, p=0.002, p=0.032, p=0.001, respectively). The urinary IP-10, MCP-1
levels were also significantly higher in the study group compared with the NOD group (p=0.038, p=0.037, respectively),
but there was no significant difference between the study and the NOD groups regarding urinary NGAL and KIM-1. In
the study group, the urinary IP-10, MCP-1, NGAL and KIM-1 levels were significantly decreased in the postoperative
period. No significant difference was detected between the study and the control groups with regard to the urinary
cystatin-C levels.
CONCLUSIONS
Based on these results, the urinary IP-10, MCP-1, NGAL and KIM-1 levels can be used as non-invasive biomarkers for
differentiating between obstruction and non-obstructive dilatation. A decrease in urinary IP-10, MCP-1, NGAL and KIM-1
levels after pyeloplasty may be used as a predictor of surgical outcome.