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ICCS S3-11
(P)
EFFICACY OF ADDING ANTICHOLINERGICS ACCORDING TO THE BLADDER
CAPACITY IN MONOSYMPTOMATIC ENURETIC PATIENTS WITHOUT RESPONSE TO
DESMOPRESSIN
Sang Hoon SONG
1
, Chanwoo LEE
1
, Jaeyoon JUNG
1
, Dong Soo RYU
2
and Kun Suk KIM
1
1) Asan Medical Center, University of Ulsan College of Medicine, Department of Urology, Seoul, KOREA (REPUBLIC OF) -
2) Sungkyunkwon University Changwon Samsung Hospital, Department of Urology, Changwon, KOREA (REPUBLIC OF)
PURPOSE
We analyzed and compared the outcome of desmopressin monotherapy and the additional effect of anticholinergics
between those with or without small bladder capacity in monosymptomatic enuresis patients.
MATERIAL AND METHODS
We retrospectively reviewed medical records of 150 patients with monosymptomatic enuresis, who visited our clinic.
According to their bladder capacity, patients were divided into small bladder capacity (SBC) group or normal group.
Small bladder capacity was defined when the patient’s maximal voided volume in voiding diary was less than 65% of
age-matched estimated bladder capacity. We stratified response to medication as complete, partial, or no response and
analyzed the difference of therapeutic effect in each group.
RESULTS
After excluding 25 patients treated without medication, a total of 125 patients (average age of 7.9 years) were included
in this study. The average follow-up duration was 11.4 (1-60) months. The proportion of male was higher in group
without SBC than in group with SBC (80.8% vs. 59.6%, p=0.009). Patients of both groups responded (complete or
partial response) similarly by the initial treatment with desmopressin (50.7% vs. 46.2%, p=0.617). In patients without
response to desmopressin, we added anticholinergic agents. The response rate was higher in both groups (80.5% and
71.4%, p=0.727) after adding anticholinergics.
CONCLUSIONS
Anticholinergic agent was useful even in the treatment in monosymptomatic enuresis patients without respond to
demopressin, regardless of bladder capacity. We speculate that administration of anticholinergics could be useful for
desmopressin non-responders, even when the functional bladder capacity estimated from voiding diary is normal.