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S17: TESTIS 1
Moderators: Magdalena Fossum (Sweden), David Diamond (USA)
ESPU Meeting on Friday 16, October 2015, 14:26 - 15:14
14:26 - 14:29
S17-1
(PP)
★
PROSPECTIVE STUDY OF HISTOLOGICAL AND ENDOCRINE PARAMETERS OF
GONADAL FUNCTION IN BOYS WITH CRYPTORCHIDISM
Gilvydas VERKAUSKAS
1
, Dalius MALCIUS
2
, Audrone EIDUKAITE
3
, Juozas VILIMAS
1
, Vytautas BILIUS
1
and Faruk
HADZISELIMOVIC
4
1) Faculty of Medicine, Vilnius University, Children's Surgery Centre, Vilnius, LITHUANIA - 2) Lithuanian University of
Health Sciences, Department of Pediatric Surgery, Kaunas, LITHUANIA - 3) State Research Institute Centre for
Innovative Medicine, Vilnius, LITHUANIA - 4) Kindermedizinisches Zentrum, Liestal, SWITZERLAND
PURPOSE
To evaluate relationship between hormonal parameters and histological findings on testicular biopsy during orchidopexy
in boys with cryptorchidism.
MATERIAL AND METHODS
72 boys operated for cryptorchidism were included prospectively. Serum samples were drawn at the start of anesthesia.
Measurements of LH, FSH, testosterone and Inhibin B were performed. Biopsies of the ipsilateral testis were performed
during orchidopexy. At the histological examination by light microscopy of semi thin sections tubular fertility index (TFI),
Ad spermatogonia count and Ad /tubular index (Ad/T) were evaluated. The results were compared in several groups –
under 18 months of age and older, with and without Ad spermatogonia, unilateral and bilateral cryptorchidism.
Moreover, two extreme groups according to TFI (high infertility risk group (HIR) with TFI <0.15% and low infertility risk
group (LIR) with TFI >95% were compared.
RESULTS
The median age was 15 months (7-65). 62% were under 18 months of age, 24% had bilateral cryptorchidism, and
42% had no Ad spermatogonia on histology. There was significantly higher median TFI and Ad/T in the group under 18
months of age. LIR group had median LH values 1.14 IU/l while HIR group had median LH 0.2 IU/l (p<0.02). FSH level
was significantly higher in older patients group. There was significant negative correlation between age and TFI and
Ad/T index. There was no significant difference in unilateral and bilateral groups in TFI, Ad/T and hormonal
concentration.
CONCLUSIONS
Lack of the Ad spermatogonia in biopsies of undescended testicles was a frequent finding in our series. High infertility
risk group had significantly lower basal LH values indicating a hypogonadotropic hypogonadism. Fertility parameters
appeared to worsen with age. Hormonal levels in the serum of cryptorchid boys could not predict the histological
findings of a single biopsy.