Abstract Book - 26th ESPU Congress, Joint Meeting with ICCS + SPU + AAP/SOU + AAPU + SFU

S22-20

(P)

PREVALENCE OF PATIENT-REPORTED LOWER URINARY TRACT SYMPTOMS AND

BOTHER IN MUSCULAR DYSTROPHY

Laura BERTRAND

, Eric J. ASKELAND

, Katherine D. MATHEWS

, Bradley A. ERICKSON

and Christopher S. COOPER

1) University of Iowa Hospitals and Clinics, Urology, Iowa City, USA - 2) University of Iowa Hospitals and Clinics,

Pediatric Neurology, Iowa City, USA

PURPOSE

Duchenne and Becker muscular dystrophies (DMD/BMD) are due to mutations in the dystrophin gene, essential for

skeletal muscle functioning, and characterized by progressive muscle weakness and loss of ambulation. The role of

dystrophin in smooth muscle function, however, is unclear. In a prior retrospective review, we demonstrated roughly

50% of DMD/BMD patients have at least one urologic diagnosis, most commonly lower urinary tract symptoms (LUTS).

In order to better understand the frequency of LUTS and the degree to which they impact quality of life (QOL), we

performed a prospective evaluation.

MATERIAL AND METHODS

Surveys, which contained questions derived from multiple validated questionnaires, including the AUA Symptom Score

and the Dysfunctional Voiding Symptoms Score, were distributed to DMD/BMD patients to assess the frequency of LUTS

(i.e. urgency, frequency, enuresis and dysuria) and how bothersome patients found these symptoms.

RESULTS

Of the 56 respondents (mean age 15.3), forty (71.4%) reported at least one LUTS, most commonly urgency (n = 31,

55%) and hesitancy of stream (n = 32, 57%). Although the majority of the patients reported being happy with their

symptoms, 16% (n = 9) expressed dissatisfaction. We did not find any correlation between LUTS and disease

progression, as measured by years non-ambulatory, on χ

analysis.

CONCLUSIONS

In this first prospective study on the frequency and degree of bother of LUTS in DMD/BMD patients, we found a high

percentage experience LUTS. Despite this high prevalence, the majority report these symptoms do not negatively

impact their QOL, however, 16% express dissatisfaction with their LUTS. Screening for bothersome LUTS should be a

part of disease management with referral to a urologist for those bothered by their symptoms to in order to improve

their QOL.