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ESPUN S3-3
(O)
PROSPECTIVE EVALUATION OF PERISTEEN® ENEMA WITH THE VALIDATED
NEUROGENIC BOWEL DYSFUNCTION SCORE SHEET IN THE PEDIATRIC
POPULATION
Maryellen KELLY
1
, Crystal DORGALLI
2
, Gordon MCLORIE
2
and Antoine KHOURY
2
1) University of California Irvine/CHOC Children's Hospital, Paediatric Urology, Orange, USA - 2) CHOC Children's
Hospital, Urology, Orange, USA
PURPOSE
Poor neurogenic bowel (NBo) control leads to emotional, physical, and psychological distress. Adequate assessment of
bowel programs’ in decreasing symptoms of NBo is vital for accurate treatment. Our objective was to determine the
ability of Peristeen®enema to reduce symptoms of NBo in patients using the only validated NBo dysfunction scoring
system for the pediatric population.
MATERIAL AND METHODS
Patients 6-18 years with NBo whose current bowel program was unsuccessful were given the Neurogenic Bowel
Dysfunction (NGBD) score sheet before initiating Peristeen®,and again at 2 weeks (n=24), 2 months (n=9) and 6
months (n=12) after initiation. All patients were started on Peristeen®with tap water calculated to 20ml/kg per daily
irrigation. Mean and paired t-tests were completed comparing NGBD scores.
RESULTS
Mean NGBD score at initiation was 20.30 (SD+/-5.66). At 2-weeks the mean score was 12.78 (SD+/- 4.49), with a
mean decrease of 7.52 points (SD+/- 5.77, 95%CI 5.02-10.02), t(23)=6.255,p<0.008. Paired t-test comparing the
NGBD score at initiation to 2-month follow-up revealed t(8)=2.83, p=0.022 with a mean decrease of 7.67 points (SD+/-
3.89). At six-months the mean NGBD score was 8.81 (SD+/- 2.40) with a paired t-test of t(11)=5.28, p<0.008.
CONCLUSIONS
Use of Peristeen®enema shows a significant reduction in NGBD scores. A steady decrease in the NGBD score was found
in those who used the device. The Peristeen®enema system should be considered when conservative bowel
management techniques are unsuccessful in children with NBo.