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(PP)
COMPARISON OF RESULTS OF ENDOSCOPIC CORRECTION OF VESICOURETERAL
REFLUX IN CHILDREN USING TWO BULKING SUBSTANCES:
DEXTRANOMER/HYALURONIC ACID COPOLYMER (DEFLUX) VERSUS
POLYACRYLATE-POLYALCOHOL COPOLYMER (VANTRIS)
Stanislaw WARCHOL
1
, Teresa DUDEK-WARCHOL
1
, Grazyna KRZEMIEN
2
, Agnieszka SZMIGIELSKA
2
, Przemyslaw
BOMBINSKI
3
and Michal BRZEWSKI
3
1) Medical University of Warsaw, Department of Pediatric Surgery and Urology, Warsaw, POLAND - 2) Medical University
of Warsaw, Department of Pediatrics and Nephrology, Warsaw, POLAND - 3) Medical University of Warsaw, Department
of Pediatric Radiology, Warsaw, POLAND
PURPOSE
The aim of the study was to evaluate the efficacy of 2 bulking substances: Deflux versus Vantris in children with VUR.
MATERIAL AND METHODS
From 2009 to 2012, 65 children (39 girls and 23 boys) aged 1.45 - 9.9 years (mean 4.85 ± 2.52) underwent endoscopic
correction of VUR using Deflux. VUR was unilateral in 31 and bilateral in 34 patients comprising 108 renal refluxing units
(RRUs) grades: II in 52, III in 47, IV in 7 and V in 2. From 2012, 68 children (43 girls and 25 boys) aged 0.6 -17.9
years (mean 4.89 ± 3.46) were treated with Vantris. VUR was unilateral in 33 and bilateral in 35 patients comprising
109 RRUs grades: II in 48, III in 29, IV in 13 and V in 19. Follow-up studies included ultrasound scan 2 weeks after
injection and voiding cystourethrogram 3 months after procedure.
RESULTS
All patients completed follow-up. In the majority of patients ultrasound showed Vantris deposit within the bladder wall
as compared with Deflux. Reflux resolved in 68 RRUs (63%) after first Deflux injection, in 30 (27,8%) after second and
in 10 (9,2%) after third. VUR was corrected in101 RRUs (92,7%) after first Vantris injection and in 8 (7,3%) after
second. No complication related to injection were noted.
CONCLUSIONS
Our data show that Vantris injection is safe and effective procedure for treating all grades of VUR with good clinical
outcome and provides higher and almost complete level of reflux resolution after first injection as compared with Deflux.