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S12: HYPOSPADIAS 1
Moderators: Ross Decter (USA), Pierre Mouriquand (France)
ESPU Meeting on Friday 16, October 2015, 08:00 - 09:00
08:00 - 08:03
S12-1
(PP)
★
SOCIO-ECONOMIC OUTCOMES FOR ADULT MEN BORN WITH HYPOSPADIAS; A
REGISTRY-BASED STUDY
Anna SKARIN NORDENVALL
1
, Louise FRISÉN
2
, Anna NORDENSTRÖM
3
, Catarina ALMQVIST MALMROS
4
and Agneta
NORDENSKJÖLD
5
1) Karolinska Institutet, Deperment of Women's and Children's Health, Stockholm, SWEDEN - 2) Karolinska Institutet,
Department of Clinical Neuroscience, Stockholm, SWEDEN - 3) Karolinska Institutet, Department of Molecular Medicine
and Surgery, and Center for Molecular Medicine, Stockholm, SWEDEN - 4) Karolinska Institutet, Department of Medical
Epidemiology and Biostatistics, Stockholm, SWEDEN - 5) Karolinska Institutet, Department of Women's and Children's
Health, Pediatric Surgery Unit and Center for Molecular Medicin, Stockholm, SWEDEN
PURPOSE
The majority of long-term follow-up studies of men with hypospadias focus on cosmetic results, sexual function and
fertility. Some studies have suggested that men with hypospadias report lower health-related quality of life and mental
health problems to a greater extent than healthy men. It is still unknown to which extent this affects the general well-
being in adulthood.
MATERIAL AND METHODS
Register-based cohort-study including men diagnosed with hypospadias, born in Sweden 1969-1993. Patients with
hypospadias were matched with 100 randomly selected non-affected males by birth year and birth county. The following
prospectively collected socio-economic outcomes served as proxies for well-being in adulthood: 1) marriage 2) biologic
children 3) eligibility to upper secondary school 3) highest level of education achieved 4) highest level of income
achieved 5) presence of disability pension. The associations between hypospadias and socio-economic outcomes were
estimated with conditional logistic regression, expressed in OR (95% CI). All analyses were performed using SAS®,
version 9.3.
RESULTS
4738 men with hypospadias were included. 53% were diagnosed with glandular or penile hypospadias, 4.6% were
diagnosed with penoscrotal or perineal hypospadias. Men born with hypospadias were less likely to be eligible for upper
secondary school, OR 0.85 (0.76-0.95), but achieved the same level of education and income as non-affected. No
differences in probabilities of being married, OR 1.0 (0.89-1.12), or having children, OR 0.94 (0.86-1.04), were
observed regardless the severity of hypospadias. An increased probability of obtaining disability pension was detected
among all severities of hypospadias.
CONCLUSIONS
This register-based cohort study demonstrates that men diagnosed with hypospadias in Sweden achieve the same level
of socio-economic outcomes as non affected men, apart from an increased risk of obtaining disability pension.