Abstract Book - 26th ESPU Congress, Joint Meeting with ICCS + SPU + AAP/SOU + AAPU + SFU

S12-11

(P)

BIOMETRY OF THE HYPOSPADIC PENIS PRIOR AND AFTER TESTOSTERONE

STIMULATION - A RANDOMIZED CONTROLLED STUDY

Jose Murillo NETTO

, Kelly Christina PAIVA

, Mariana L. C. SOUZA

, Marina N. PEREIRA

, Lara M. MIRANDA

, Ubirajara

BARROSO JR.

, Andre A. FIGUEIREDO

and Jose BESSA JR.

1) Hospital e Maternidade Therezinha de Jesus da Faculdade de Ciências Médicas e da Saúde de Juiz de Fo, Surgery -

Division of Urology, Juiz De Fora, BRAZIL - 2) Hospital e Maternidade Therezinha de Jesus da Faculdade de Ciências

Médicas e da Saúde de Juiz de Fo, Surgery - Division of Pediatric Surgery, Juiz De Fora, BRAZIL - 3) Federal University

of Juiz de Fora (UFJF), Surgery - Division of Urology, Juiz De Fora, BRAZIL - 4) Federal University of Bahia (UFBA),

Surgery - Division of Urology, Juiz De Fora, BRAZIL - 5) State University of Feira de Santana (UEFS), Surgery - Division

of Urology, Juiz De Fora, BRAZIL

PURPOSE

The use of preoperative hormonal stimulation prior to hypospadias correction aims to increase penile size and achieve

better surgical results. Its rule is still not clear in the literature. We evaluated the effects of topical testosterone on the

morphometry of the hypospadic penis and its side effects.

MATERIAL AND METHODS

Thirty-seven children with hypospadias were randomly divided into tow groups: GT: 24 boys used 1% topical

testosterone propionate twice a day for 30 days and GC: 13 children use placebo for the same period. Blood

Testosterone, FSH and LH tests were done prior, 30, and 90 days after treatment. Biometric evaluation of the penis,

including penile length at maximum stretch, diameter of the penile body and glans, distance from the meatus to the tip

of the penis, and width of the urethral plate, were measured.

RESULTS

Hypospadias classification in GT were anterior (12), midshaft (5), and posterior (7) and in GC were anterior (9),

midshaft (2), and posterior (2). Only one child in GT had increased hormone levels after 30 and 90 days of treatment.

After 30 days 83% (20/24) of children in GT had pubic hair growth, and 91.6% (22/24) had darkening of genital skin.

These effects were not seen in any boys of GC. After 90 days, pubic hair growth was seen in 16.6% (4/24) and

darkening of the skin persisted in 4.2% (1/24). All biometric measures of the penis increased in GT but only the

diameter of the glans was significant (P: 0.0355). There was no increase in these measures in GC.

CONCLUSIONS

Preoperative use of topical testosterone increases the size of the penis, especially the diameter of the glans. No

significant side effects were seen and hormonal levels and virilizations signs desapear after 90 days of treatment.