Abstract Book - 26th ESPU Congress, Joint Meeting with ICCS + SPU + AAP/SOU + AAPU + SFU

S12-15

(P)

SHORTER ANOGENITAL DISTANCE CORRELATES WITH SEVERITY OF

HYPOSPADIAS IN PRE PUBERTAL BOYS

Arbinder Kumar SINGAL

, Viral JAIN

and Zarine GAZALI

1) Hypospadias Foundation & MITR Hospital, MGM Hospital, Vashi, Navi Mumbai, Pediatric urology, Navi Mumbai, INDIA

- 2) MetroHealth, Case Western Reserve University, Pediatrics, Cleveland, USA - 3) Hypospadias Foundation & MITR

Hospital, Pediatric urology, Navi Mumbai, INDIA

PURPOSE

Anogenital distance (AGD) is a sensitive bio-marker of fetal androgen disruption. Animal studies have reported a critical

time period during early gestation where androgen deficiency results in reduced AGD as well as cryptorchidism and

hypospadias. AGD in pre-pubertal boys with hypospadias in not well studied.

MATERIAL AND METHODS

We measured AGD from the midpoint of anus to (1) ASD -bottom of scrotum, (2) AGD1 –penopubic junction (3) AGD2 –

penoscrotal junction; in all boys presenting with hypospadias. We selected age-matched controls without any genital

anomalies.

RESULTS

139 boys with hypospadias and 267 controls were studied. In boys with hypospadias compared to controls we found no

significant difference in weight (13.6±6.1 kg vs 14.8±6.8 kg, p=0.080), height (94.1±20.1 cm vs 93.5±19.9 cm,

p=0.776) and age (45.12±35.53 months vs 46.79±33.05 months, p=0.637). We found significant difference only in

ASD (40.00±9.68 vs 45.60±9.35, p<0.001). No significant difference was observed in AGD1 (78.91±12.33 cm vs

80.2±14.10 cm, p=0.367) and AGD 2 (69.90±13.06 cm vs 71.64±13.81 cm, p=0.273).

Age, weight and length adjusted regression model showed significantly shorter ASD (p <0.001) but not AGD1 (p=0.509)

and AGD2 (p=0.149) in boys with hypospadias. We saw a negative correlation (r= -0.297, -0.267, -0.327, p<0.001)

with severity of hypospadias with all three measures of AGD respectively

CONCLUSIONS

AGD is significantly shorter in boys with hypospadias and decreases with severity of hypospadias. This study strengthens

the utility of AGD as a non-invasive predictor of male reproductive health outcomes.