Abstract Book - 26th ESPU Congress, Joint Meeting with ICCS + SPU + AAP/SOU + AAPU + SFU

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ICCS S3: NOCTURNAL ENURESIS
Moderators: Johan vande Walle (Belgium) & Jens Christian Djurhuus (Denmark)
ICCS Meeting on Friday 16, October 2015, 08:00 - 09:00
08:00 - 08:06
ICCS S3-1 (LO)
EFFECTIVE TREATMENT OF NOCTURNAL ENURESIS RESULTS IN AMELIORATION
OF NEUROCOGNITIVE DYSFUNCTION AND DISRUPTED SLEEP.
Johan VANDE WALLE1, Charlotte VAN HERZEELE1, Karlien DHONDT2, Sanne ROELS3, Ann RAES1, Piet HOEBEKE4 and
Luitzen-Albert GROEN4
1) University Hospital Ghent, Pediatric Nephrology, Ghent, BELGIUM - 2) University Hospital Ghent, Department of Child
Neurology and Metabolism, Pediatric Sleep Center, Ghent, BELGIUM - 3) University Ghent, Data-analyses, Ghent,
BELGIUM - 4) University Hospital Ghent, Pediatric Urology, Ghent, BELGIUM
PURPOSE
The high comorbidity between nocturnal enuresis, sleep disorders and psychological problems is suggestive of a
common pathway in the central nervous system. This study aims to evaluate the effect of a simple therapeutic
intervention for nocturnal enuresis on the major comorbidities: disrupted sleep and neuropsychological dysfunction.
MATERIAL AND METHODS
In this open-label, prospective phase IV study, children with monosymptomatic nocturnal enuresis associated with
nocturnal polyuria, underwent standardized video-polysomnographic testing and multi-informant neuropsychological
testing at baseline and 6 months after the start of desmopressin treatment. The primary endpoints were the change in
sleep and neuropsychological functioning. Neuropsychological functioning was measured on five domains: quality of life,
attention, executive function, internalizing problems and externalizing problems. The secondary endpoint was the
change in the first undisturbed sleep period or the time to the first void.
RESULTS
Thirty-nine patients were screened and 35 patients were included in the study and completed the first examination.
Thirty children (23 boys and 7 girls) between 6 and 16 years (mean 10.43, SD 3.08) completed the study. Response
rate to desmopressin was 82%. The study demonstrated a significant decrease in periodic limb movements during sleep
(F(1,26)= 122.50, p<0.001 [95% CI, -6.26 to -3.27]) and a prolonged first undisturbed sleep period. Additionally
neuropsychological functioning was improved on several domains: quality of life, executive functioning, internalizing
problems and externalizing problems.
CONCLUSIONS
This study demonstrates that effective treatment of nocturnal polyuria in children with monosymptomatic nocturnal
enuresis has a beneficial effect on sleep disruption and neuropsychological dysfunction.