451 / 492
08:18 - 08:24
ICCS S3-4
(LO)
ISOLATED REDUCED NOCTURNAL BLADDER RESERVOIR FUNCTION - A NEW TYPE
OF NOCTURNAL ENURESIS
Britt BORG
1
, Konstantinos KAMPERIS
2
and Søren RITTIG
2
1) Aarhus Universityhospital, Pediatric dep., A-Researchlab, Aarhus N, DENMARK - 2) Aarhus Universityhospital,
Pediatric dep., Aarhus N, DENMARK
PURPOSE
Bladder reservoir function in children with monosymptomatic nocturnal enuresis (MNE) is assessed by maximal voided
volumes (MVV) registered on frequency-volume charts during daytime. Although a degree of association is evident, MVV
does not necessarily reflect the nocturnal bladder reservoir function in MNE. We aimed to evaluate the nocturnal bladder
reservoir function during the night in children with a normal MVV.
MATERIAL AND METHODS
Data from 239 children aged 5-15 treated for MNE in a tertiary referral centre was collected for a nested cohort study.
Data from 99 children was excluded due to reduced MVV according to ICCS standardization and 34 were lost to follow-
up. The remaining 106
were divided into two groups, based on whether they experienced wet nights with nocturnal
urine production (NUP) below MVV.
RESULTS
82 % of the children with MNE and a normal bladder capacity experienced wet nights with NUP below their MVV. The
mean proportion of wet nights with NUP below MVV was 49 % and below MVV expected for age (MVV
Age
) the proportion
was 23 %. Desmopressin response was negatively correlated with proportion of wet nights with NUP below MVV. The
children with an occurrence of wet nights with NUP below MVV above 40 % had 11 % response rate for desmopressin
treatment. Furthermore these children shared higher maximal NUP on dry nights than minimal NUP on wet nights.
CONCLUSIONS
Most children with MNE and normal MVV during daytime experience wet nights with urine volumes well below their MVV
and MVV
Age
, the latter could be viewed as isolated reduced nocturnal bladder reservoir function. This indicates bladder
reservoir function abnormalities during sleep that is not assessed by day recordings. Physicians treating children with
MNE should consider anticholinergic and combination treatment.