Abstract Book - 26th ESPU Congress, Joint Meeting with ICCS + SPU + AAP/SOU + AAPU + SFU

08:24 - 08:28

ICCS S3-5

(SO)

URINARY NERVE GROWTH FACTOR CAN BE A BIOMARKER FOR PREDICTING

THERAPEUTIC SUCCESS IN MONOSYMPTOMATIC NOCTURNAL ENURESIS

Katsuya AOKI, Shinji FUKUI, Yosuke MORIZAWA, Makito MIYAKE and Kiyohide FUJIMOTO

Nara Medical University, Department of Urology, Kashihara, JAPAN

PURPOSE

Primary monosymptomatic nocturnal enuresis (MNE) is caused by a complex set of conditions, involving a mismatch

between nocturnal diuresis and bladder capacity as well as a disturbance of arousal before micturition, but there have

not been sufficient investigations regarding the relationship between MNE and bladder function. Urinary nerve growth

factor (NGF) is considered a potential biomarker for overactive bladder syndrome in both children and

this

study we measured urinary NGF in children with MNE and evaluated the relationship between MNE and urinary NGF as a

predicting factor of therapeutic success.

MATERIAL AND METHODS

Urine samples were collected from 31 children (24 boys and 7 girls, mean age: 9.3 years) with MNE before treatment

and 11 children (6 boys and 5 girls, mean age: 10.0 years) without MNE as a control group. Urinary NGF levels were

measured by using ELISA assay. NGF levels were normalized to the concentration of urinary creatinine. After 3 months

of desmopressin or alarm treatment, treatment outcomes were assessed. The disparity of urinary NGF/Cr was evaluated

between the MNE and in a control groups, and the relationship between urinary NGF/Cr and treatment outcome was

evaluated.

RESULTS

Urinary NGF/Cr was significantly higher in the MNE group, compared with the control group (0.67±0.69 vs. 0.11±0.09,

p=0.0003). After treatment, success (defined as more than 90% reduction in wet nights per month) was achieved in

37% of patients in the MNE group. Urinary NGF/Cr was significantly lower in the treatment-success group, compared

with the non-success group (0.18±0.15 vs. 0.93±0.86, p=0.0009).

CONCLUSIONS

Urinary NGF/Cr was significantly higher in children with MNE than in controls and was lower in the treatment-success

group than in the non-success group. Urinary NGF/Cr may become a potential biomarker for MNE and a predictor of

treatment outcome for patients with MNE.