Abstract Book - 26th ESPU Congress, Joint Meeting with ICCS + SPU + AAP/SOU + AAPU + SFU

BSP-18

(P)

URODYNAMIC EVALUATION OF BLADDER DIERTICULA IN AN EXPERIMENTAL

STUDY IN RABBITS

Suleyman CELEBI

, özgür KUZDAN

and Serdar SANDER

1) Kanuni Sultan Suleyman Education and Research Hospital, Department of Pediatric Surgery, Istanbul, TURKEY - 2)

Kanuni Sultan Suleyman Education and Research Hospital, Department of Pediatric Surgery, Division of Pediatric

Urology, Istanbul, TURKEY

PURPOSE

It has not been determined whether dysfunctional voiding causes diverticula, or if congenital diverticula is responsible

for dysfunctional voiding. This study evaluates the effect of bladder diverticula on bladder function in a rabbit model

based on urodynamic findings.

MATERIAL AND METHODS

In total, 24 New Zealand white rabbits were randomized to four groups (n=6 per group): 1) sham surgery; 2) a single,

1-cm-diameter diverticulum; 3) a single, 3-cm-diameter diverticulum; and 4) four 1-cm-diameter diverticula.

Urodynamic evaluations were performed preoperatively and 1 week and 1 month postoperatively, to measure the post-

micturition residual (PMR), maximum bladder capacity (MBC), detrusor pressure (Pdet), compliance and unstable

detrusor contractions. Statistical significance was determined using Kruskal-Wallis and Student's t-test.

RESULTS

In groups 1 and 2, the MBC, Pdet, and compliance were within the reference ranges and none of the rabbits had PMR. In

groups 3 and 4, the rabbits all had PMR. At 30 days after surgery, the MBC was 28% and 31% lower than the reference

range in groups 3 and 4, respectively, and compliance was decreased (p<0.05). Further, the Pdet was significantly

higher than in rabbits with 1-cm diverticula or those in the sham group (p<0.05). Group 3 had unstable detrusor

contractions.

CONCLUSIONS

Large or multiple bladder diverticula alter bladder storage and emptying, and can decrease the capacity of the bladder

and reduce its elasticity, causing higher pressures with reduced volumes. In other words, compliance is decreased.

Large or multiple bladder diverticula can cause dysfunctional voiding.